2021.09.20 22:40 adapt313 Zucas available anywhere?
Looking for a zuca all terrain cart for a while now and they've been out of stock everywhere I've looked for some time. Anyone have any sites that have the all terrain model in stock currently or have any idea when they may be restocked?
submitted by adapt313 to discgolf [link] [comments]
2021.09.20 22:40 wadeboggsbosshoggs First decent day in a while
2021.09.20 22:40 dem0n0cracy Central activation of TRPV1 and TRPA1 by novel endogenous agonists contributes to mechanical and thermal allodynia after burn injury
Central activation of TRPV1 and TRPA1 by novel endogenous agonists contributes to mechanical and thermal allodynia after burn injury Show all authorsDustin P Green, PhD, Shivani Ruparel, PhD, Xiaoli Gao, PhD, ...First Published July 12, 2016 Research Article Find in PubMed📷https://doi.org/10.1177/1744806916661725Article information 📷📷
Abstract The primary complaint of burn victims is an intense, often devastating spontaneous pain, with persistence of mechanical and thermal allodynia. The transient receptor potential channels, TRPV1 and TRPA1, are expressed by a subset of nociceptive sensory neurons and contribute to inflammatory hypersensitivity. Although their function in the periphery is well known, a role for these TRP channels in central pain mechanisms is less well defined. Lipid agonists of TRPV1 are released from peripheral tissues via enzymatic oxidation after burn injury; however, it is not known if burn injury triggers the release of oxidized lipids in the spinal cord. Accordingly, we evaluated whether burn injury evoked the central release of oxidized lipids. Analysis of lipid extracts of spinal cord tissue with HPLC-MS revealed a significant increase in levels of the epoxide and diol metabolites of linoleic acid: 9,10-DiHOME, 12,13-DiHOME, 9(10)-EpOME, and 12(13)-EpOME, that was reduced after intrathecal (i.t.) injection of the oxidative enzyme inhibitor ketoconazole. Moreover, we found that these four lipid metabolites were capable of specifically activating both TRPV1 and TRPA1. Intrathecal injection of specific antagonists to TRPV1 (AMG-517) or TRPA1 (HC-030031) significantly reduced post-burn mechanical and thermal allodynia. Finally, i.t. injection of ketoconazole significantly reversed post-burn mechanical and thermal allodynia. Our data indicate that spinal cord TRPV1 and TRPA1 contributes to pain after burn and identifies a novel class of oxidized lipids elevated in the spinal cord after burn injury. Since the management of burn pain is problematic, these findings point to a novel approach for treating post-burn pain.
Keywords burn, pain, OLAM, TRPV1, TRPA1, AMG-517, HC-030031
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2021.09.20 22:40 stephorium Lets play
2021.09.20 22:40 Chinesemathgenius Bullnation
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2021.09.20 22:40 callum3214 Is motion play usuable on android?
I have finally been able to link my controller with my phone to play remotely however that app crashed after just a couple of seconds im wondering if its mainly for apple users to have this function?
submitted by callum3214 to XboxSeriesX [link] [comments]
2021.09.20 22:40 primalchrome 2021 - Named or Tier 4 Blacksmith or Armorer....How?
Map : Exiled Lands
Under the current (Sept 2021) patch, how can a player find Named / T4 Blacksmiths and Armorers? Do they still spawn at Blacksmith spawns in Freya's Camp, New Asgarth, or Mounds of the Dead? Is it only during a Purge...and if so, what Purge Level or specific biome?
The sources I've seen are either inconclusive or vague, so I'm hoping the voice of Yog will resound in this subreddit and answer me in my time of need. My group has a privately hosted server and have yet to find one. This is with daily circuits of known blacksmith spawns and a few of purges.
Thanks in advance for any help!
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2021.09.20 22:40 thesnapening Just needed a rant
So yeah I don’t have anybody who has chinchillas I can talk to so I joined this sub.
I’ve had my two for 21 years and sadly jacky has passed away in her sleep in the last couple of hours. She had a almond at about 8pm and now at 2133 I found her passed away in her sleep.
Very very sad day but thunder is still going strong, I’ve left her so he can say his goodbyes.
submitted by thesnapening to chinchilla [link] [comments]
2021.09.20 22:40 blokdijkg Cybersecurity Risk Management Kanban
Stay on top of your Cyber Risk Management; to visualize the Cybersecurity Risk Management work and maximize efficiency, I’ve just released a new Cybersecurity Risk Management Kanban board that establishes order into 1740 Work Items and has the latest insights prioritized into easy to use Workflows.
It's for where to get started on your current or impending Cyber Risk Management journey, commit to the right amount of work, and get it done!
How many tasks can you move to Done?
If you want to check it out and use it go here: https://theartofservice.com/Cybersecurity-Risk-Management-Kanban
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2021.09.20 22:40 ShoelessRocketman Well that was fun. Who else is excited for tomorrow?! We aren’t leaving!!! 💎👐🦍🚀🌕
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2021.09.20 22:40 Soho-Doll Can someone please tell me where this doll is from?
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2021.09.20 22:40 adeste82 My consumption seems off. Can anyone explain?
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2021.09.20 22:40 WillShowBoobs4Moons Buying Smile Coin on MexC. Save 10% on all trading fees for life with referral
2021.09.20 22:40 2ADad1974 New DW5600e. Semi retiring my 9052
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2021.09.20 22:40 IAmBeelzeben Come watch some cracked DBD gameplay, my cenobite game is really improving!
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2021.09.20 22:40 RobHartAuthor Free ebooks - Begin your adventures - Action & Adventure, Sci-Fi & Fantasy, and Sci-Fi & Fantasy / Horror
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2021.09.20 22:40 Cirty09 REQUEST 5【亞北ネル \ Akita Neru】どういうことなの！？ \ What do you mean !? - Vocaloid ...
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2021.09.20 22:40 Grijns_Official Balls Have a Drag Coefficient... [0:45][Comedy]
2021.09.20 22:40 saka-mulia Soros (2019) documentary
Hey all, does anyone have a copy of Soros (2019) the documentary?
I've heard it's a belter esp. about the far-right conspiracy theories about him.
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2021.09.20 22:40 Xiryts Will my libido returns if my anhedonia is in remission ?
2021.09.20 22:40 Luis1623 False start on Corey Linsley and Jerry Jones rigging
I think I remember a flag being called for a false start on our center. I just think how tf? I could be mistaken but I know for facts they called a false start on #63. Fuck Jerry Jones for paying the refs.
ALSO(I know it’s rigged) Why in the middle of the game are they talking about Jerry Jones being a huge fan of LA and his childhood home being just down the street from the stadium and blah blah blah. Completely random to have this segment in the middle of the game
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2021.09.20 22:40 sucia213 What do the ethinyl estradiol only pills during the fourth week of a pill pack do?
2021.09.20 22:40 HabiRabbit Legion 17 maximum storage? Can I upgrade it?
Hey all, I'm pretty new to the world of laptops but I've found this laptop which I'm thinking of buying:
My only problem is that it only has 512gb of storage. Would it be possible for me at some point to upgrade it to 1TB?
submitted by HabiRabbit to Lenovo [link] [comments]
2021.09.20 22:40 peppermind77 Is it true that you shed more hair in autumn?
I started to see slightly more shedding recently and was worried if the finasteride is already no longer working for me. But then a friend said to me that it's pretty normal to lose more hair at this time of the year.
Is this true? And if so, is there any explanation for this?
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2021.09.20 22:40 Domilama1 2 working 3DS'ES for 40$
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